Summary of serum escape, functional effects, and ACE2 affinities for XBB.1.5 spike deep mutational scanning

This is is an interactive chart. Mouseover points on the top line plots that summarize the per-site escape averaged across all sera and for individual sera. You can use the top zoom-bar to zoom in on specific sites to show in the heatmaps that give per-mutation effects. Options at bottom let you only show escape for sites with some minimal effect on other properties (deleterious mutations are grayed out in heatmap), choose the site summary metric, or floor the escape at zero.

Analysis by Bernadeta Dadonaite and Jesse Bloom (2023).

See https://github.com/dms-vep/SARS-CoV-2_XBB.1.5_spike_DMS for code/data.